Mass transfer kinetics on modern Whelk-O1 chiral stationary phases made on fully- and superficially-porous particles

In this work, a detailed study of mass transfer properties trans-stilbene oxide (TSO) enantiomers on two Whelk-O1 chiral stationary phases (CSPs) has been performed. The CSPs were prepared by using both fully-porous silica particles 2.5 μm particle diameter and superficially-porous ones 2.6 as base materials. By combining stop-flow dynamic measurements in normal-phase conditions, the different contributions to have estimated. intraparticle diffusion revealed that adsorption is localized (i.e., characterized absence surface diffusion). determination thermodynamic binding constants (measured through isotherms) supports finding.